In general, there is not much research about herbal or natural supplements. Little is known about their effects on bipolar disorder. A herb called St. John’s wort (Hypericum perforatum), often marketed as a natural antidepressant, may cause a switch to mania in some people with bipolar disorder.
St. John’s wort can also make other medications less effective, including some antidepressant and anticonvulsant medications. Scientists are also researching omega-3 fatty acids (most commonly found in fish oil) to measure their usefulness for long-term treatment of bipolar disorder. Study results have been mixed. It is important to talk with a doctor before taking any herbal or natural supplements because of the serious risk of interactions with other medications.